Methandrostenolone Tablets

Composition: 
Each tablet contains: 
Methandrostenolone 10 mg 

Pharmacological action: 
Has significant anabolic activity (increases protein synthesis) at a relatively low androgenic acting (similar to the action of male sex hormones). This effect is manifest in a positive nitrogen balance in the body and improves general state of person. The balance of calcium also has a positive effect: Methandrostenolone promotes the flow of calcium into bone tissue. Methandrostenolone is indicated in all diseases and conditions, in which is shown anabolic effect (accelerating growth of protein) and fortifying effect. 

Indications of Methandrostenolone: 

1. Violation of protein metabolism-asthenia (weakness) 
2. Cachexia ( extreme exhaustion) of different origin, after severe trauma, surgery, burns, infections, and other diseases associated with protein loss (infections, burns, radiation therapy, prolonged use of corticosteroids, etc.) 
3. Osteoporosis (malnutrition bone, accompanied by an increase in its fragility) 
4. In pediatric ( child) practice 
5. Growth retardation 
6. Anorexia (lack of appetite) 
7. Depression nutrition etc. 

Dosage: 
Inside of0.005-0.01 gper day before meals for children up to 2 years - a rate of0.05-0.1 mg/kg, from 2 to 5 years - 1-2 mg I day, from 6 to 14 years - 3-5 mg I day (in 1-2 divided doses). Course of treatment usually is of - 4-8 weeks. The highest single dose for adults is of-0.01 grams, daily-0.05 g. 

Side effects: 

1. Dyspeptic symptoms (indigestion) 
2. Enlargement of the liver 
3. Transient jaundice (periodically appearing yellowing of skin and mucous membranes of the eyes) 
4. Swelling 
5. Acnevulgar 
6. Women masculinization (the appearance of masculine traits at women/ coarsening of voice, muscle development etc./ under the influence of male sex hormones). 

Clenbuterol Hydrochloride 40mcg

Composition: 
Each tablet contains: 
Clenbuterol Hydrochloride BP 40 mcg 

Clinical Pharmacology: 
Clenbuterol exerts a pronounced action on the metabolism; with both anabolic and anti-catabolic effects. Clenbuterol has been demonstrated to increase the rate of protein synthesis in muscle tissue and to increase protein to fat ratio. 
Clenbuterol is a beta-2 adrenergic agonist relaxing airway muscle tissue and proving bronchodialation. Clenbuterol increases aerobic capacity, pulse perspiration and blood pressure; increases basal metabolic rate and temperature. 
Clenbuterol has an oral bioavailability of 89 to 98 % with a half- life of 36 to 48 hours after oral use. 

Indication: 
To increase the rate of protein synthesis in muscle tissue and to increase protein to fat ratio in human. 

Contraindication: 

1. Children or geriatric patients 
2. Individuals who have been diagnosed of cardio-vascular problems should not take Clenbuterol. 
3. Women who are pregnant or may become pregnant 
4. Concomitantly with other CNS stimulants, adrenergic, or hypertensive agents 
5. In patients with hypersensitivity to Clenbuterol or other ingredients 
6. In patients with a history of GI bleeding, ulceration of the stomach, or gastritis 

Precautions: 
Clenbuterol can produce significant cardiovascular effects in some patients as evidenced by elevated pulse rate, blood pressure changes and or ECG changes. The patients who use Clenbuterol should be monitored for changes in heart rate, arterial blood pressure and or oxygen saturation of arterial blood. Urticaria and tachycardia may be observed during the few first days of treatment; if this occurs; discontinue and consult physician immediately. 
Not for use by nursing mothers due to unknown effect from excreted milk. 

Use in pregnancy: 
Although animal experiments showed no teratogenic effects. 
Clenbuterol should not be used during the 1 • trimester of pregnancy because of its labour inhibiting action and it should not be taken shortly before childbirth. 

Drug Interaction: 
Clenbuterol may enhance the action and side effects of other beta -adrenergic rn.imetics, theophylline and anti- cholinergic. 
Beta blockers may inhibit the action of Clenbuterol; thus a risk of bronchospasm exists with concomitant uses. 
Clenbuterol may alter the action of hypoglycemic agents, insulin sensitizers, insulin and insulin secretagogues. Adjust of dosage may be required. Monitor for loss of glycaemic control. 
There is an increased risk of arrhythmia with concomitant administration of halogenated carbohydrates for nacrosis; e.g. during surgery. Concomitant use with diuretics and digitalis glycosides requires periodic monitoring of serum electrolytes. 
Concomitant use with other CNS stimulants should be avoided given the cumulative stimulatory effects and increased risk of adverse events. 
Concomitant use with MAO- inhibitors and tri- cyclic antidepressant may produce cardiac dysrhythmias. 

Oxandrolone Tablets USP

COMPOSITION: 
Each tablet contains: 
Oxandrolone USP 10 mg 
 

INDICATIONS: 
Certain cases of disseminated breast cancer in women. 
Osteoporosis due to androgen deficiency in hypogonadal males. 

CONTRA-INDICATIONS: 
Not intended for use in children. 
Known or suspected prostatic carcinoma and mammary carcinoma in the male. 
Not intended for use in female patients other than those with disseminated breast cancer. 
Contraindicated in nephrosis or the nephrotic phase of nephritis, cardiac and renal failure, hypercalcaemia, oedema, jaundice, liver disease with impaired bilirubin excretion, testicular and hepatic carcinoma. 
 

DOSAGE AND DIRECTIONS FOR USE: 
Dynavar should be taken orally per day in divided doses. 
Adult dose: 5-10 mg every day. 
 

SIDE-EFFECTS AND SPECIAL PRECAUTIONS: 
Vrrilisation which appears in sensitive women as hoarseness, acne, hirsutism, and increased libido; in prepubertal boys as an increased frequency of erections and phallic enlargement, and in girls as an increase of pubic hair and clitoral hypertrophy. Hoarseness may be the first symptom of vocal change which may end in a long-lasting, sometimes irreversible deepening of the voice. 
 

OTHER ADVERSE REACTIONS MAY INCLUDE: 
Oligospermia and decreased ejaculatory volume; 
Suppression of ovarian activity, atrophy of the breasts and endometrial tissue. 
Amenorrhoea and inhibition of spermatogenesis. 
Water and salt retention. 
Premature epiphyseal closure. 
If signs of virilisation develop, treatment should be discontinued. 
Increase in nitrogen retention and skeletal weight; 
Oedema; 
Increased vascularity of the skin; 
Increased growth of the bone; 
Elderly males may become over-stimulated. 

Stanozolol Tablets USP 10mg/ml

COMPOSITION: 
Each tablet contains: 
Stanozolol USP 10 mg 

Indications and usage: 
Hereditary Angioedema: for prophylactic use to decrease frequency and severity ofattacks of angioedema. 
Muscle Anabolism: for adjunctive therapy in patients for weight gain following severe muscular atrophy associatedwith extensive surgery, chronic infections, long term hospitalization, or sever trauma. 
Corticosteroid atrophy: to reduce muscle wasting during prolonged corticosteroid use. 

Drug interactions: 
Dyoawin may increase sensitivity to anticoagulants; therefore, dosage of an anticoagulant may have to be decreased in order to maintain the prothrombin time at the desired therapeutic level. 

Overdosage : 
Cholestatic hepatitis and jaundice occur with 17 alpha alkylated androgens at relatively low doses. If cholestic hepatitis with jaundice appears the stanozolol dose should be discontinued. If liver function tests become abnormal, the patient should be monitored closely and the aetiology determined. In patient with breast cancer anabolic steroid may cause hypercalcemia by stimulating osteolysis in this case the drug should be discontinued. 
Edema with or without congestive heart failure may be a serious complication in patients with pre existing cardiac, renal, or hepatic disease. 

Precautions: 
General: Women should be observed for signs of virilisation ( deepening of the voice, hirsutism, acne, and clitoromegaly). To prevent irreversible change, drug therapy must be discontinued, or the dosage significantly reduced. Such virilisation is usnal following androgenic anabolic steroid use at high doses. Some virilising changes in women are irreversible even after prompt discontinuance of therapy and are not prevented by concomitant use of estrogens. Menstrual irregularities may also occur. The insulin or oral hypoglycemic dosage may need adjustment in diabetic patients who receive anabolic steroids. 
Information for the Patient. The physician should instruct patients to report any of the following side effects of androgens: